Reducing False Negative PCR Test for COVID-19

Authors

  • Fatemeh Bahreini, PhD Department of Molecular Medicine and Genetics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  • Rezvan Najafi, PhD Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  • Razieh Amini, PhD Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  • Salman Khazaei, PhD Modeling of Non-communicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  • Saeid Bashirian, PhD Department of Public Health, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

DOI:

https://doi.org/10.21106/ijma.421

Keywords:

SARS-CoV-2, COVID-19, Real time polymerase chain reaction, RT-PCR test, Diagnosis , False negatives, Genetics , Emerging disease

Abstract

As the SARS-CoV-2 (COVID-19) pandemic spreads rapidly, there is need for a diagnostic test with high accuracy to detect infected individuals especially those without symptoms. Real-time polymerase chain reaction (RT-PCR) is a common molecular test for diagnosing SARS-CoV-2. If some factors are not taken into consideration when performing this test, it can have a relatively large number of false negative results. In this article, we discuss important considerations that could lead to false negative test reduction.

 

Copyright © 2020 Bahreini et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.

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Publication History

Issue

Vol. 9 No. 3

Section

Letter to the Editor

License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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