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    Formulation and Evaluation of Mucoadhesive Buccal tablets using Nimodipine Solid Lipid Nanoparticles



    Abstract

    This study aimed to create and describe mucoadhesive nimodipine solid lipid nanoparticles as buccal tablets by altering the amounts of three polymers: Carbopol 934, Hydroxypropyl methylcellulose and Hydroxyethyl cellulose. The Nimodipine-loaded solid lipid nanoparticles (SLN) were formulated by high shear homogenization and ultrasonication process using palmitic and stearic acid as the lipid matrix and Tween-80 as the surfactant. The swelling properties of all formulations were investigated, and it was discovered that all formulations have a good swelling index at 6 hours. The surface pH of each batch varied between 5.6 and 6.1. The mucoadhesive strengths (15.3-29.5 g) varied with polymer concentrations, particularly Carbopol 934. All batches had considerably different dissolution profiles, ranging from a maximum release of 89.08% (at 8h in batch NT3) to a minimum release of 80.32% (at 8h in batch NT2). SLN formulations had the best results in both Entrapment efficiency and In-vitro drug release, showing that SLN may be a promising delivery strategy for improving Nimodipine release.

    Keywords: Nimodipine Mucoadhesive buccal tablets Carbopol 934 Hydroxypropyl methylcellulose Hydroxyethyl cellulose Solid lipid nanoparticles
    Section

    References

    1. Akter, M., Banik, S., & Hossain, M. S. (2012). In vitro evaluation of oral extended release drug delivery system for metoprolol succinate using Kollidon SR. Journal of Applied Pharmaceutical Science, 2(5), 188–192. https://doi.org/10.7324/JAPS.2012.2539
    2. Andrews, G. P., Laverty, T. P., & Jones, D. S. (2009). Mucoadhesive polymeric platforms for controlled drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 71(3), 505–518. https://doi.org/10.1016/J.EJPB.2008.09.028
    3. Arabi, M., Mortazavi, S. A., Jafariazar, Z., Farhadnejad, H., Haris, G. A., & Fatahi, Y. (2020). Fabrication and in-vitro evaluation of buccal mucoadhesive tablet of meloxicam. Iranian Journal of Pharmaceutical Research, 19(3), 63–76. https://doi.org/10.22037/ijpr.2019.111820.13378
    4. Bernkop-Schnürch, A. (2005). Mucoadhesive systems in oral drug delivery. Drug Discovery Today: Technologies, 2(1), 83–87. https://doi.org/10.1016/J.DDTEC.2005.05.001
    5. Boddupalli, B. M., Mohammed, Z. N. K., Nath A., R., & Banji, D. (2010). Mucoadhesive drug delivery system: An overview. Journal of Advanced Pharmaceutical Technology and Research, 1(4), 381–387. https://doi.org/10.4103/0110-5558.76436
    6. Chalikwar, S. S., Belgamwar, V. S., Talele, V. R., Surana, S. J., & Patil, M. U. (2012). Formulation and evaluation of Nimodipine-loaded solid lipid nanoparticles delivered via lymphatic transport system. Colloids and Surfaces B: Biointerfaces, 97, 109–116. https://doi.org/10.1016/j.colsurfb.2012.04.027
    7. Drug, M., & Systems, D. (1993). M a Rosa Jim&nez-Castellanos2, Hussein Zial and C. T. Rhodes’ Department of Pharmaceutics, University of Rhocle Island, Kingston, RI 02881. 19, 143–194.
    8. Harris, D., & Robinson, J. R. (1992). Drug delivery via the mucous membranes of the oral cavity. Journal of Pharmaceutical Sciences, 81(1), 1–10. https://doi.org/10.1002/jps.2600810102
    9. Henriksen, I., Green, K. L., Smart, J. D., Smistad, G., & Karlsen, J. (1996). Bioadhesion of hydrated chitosans: An in vitro and in vivo study. International Journal of Pharmaceutics, 145(1–2), 231–240. https://doi.org/10.1016/S0378-5173(96)04776-X
    10. Hosny, K. M., Banjar, Z. M., Hariri, A. H., & Hassan, A. H. (2015). Solid lipid nanoparticles loaded with iron to overcome barriers for treatment of iron deficiency anemia. Drug Design, Development and Therapy, 9, 313–320. https://doi.org/10.2147/DDDT.S77702
    11. Huang, Y., Leobandung, W., Foss, A., & Peppas, N. A. (2000). Molecular aspects of muco- and bioadhesion:: Tethered structures and site-specific surfaces. Journal of Controlled Release, 65(1–2), 63–71. https://doi.org/10.1016/S0168-3659(99)00233-3
    12. Kianfar, F., Antonijevic, M. D., Chowdhry, B. Z., & Boateng, J. S. (2011). Formulation Development of a Carrageenan Based Delivery System for Buccal Drug Delivery Using Ibuprofen as a Model Drug. Journal of Biomaterials and Nanobiotechnology, 02(05), 582–595. https://doi.org/10.4236/jbnb.2011.225070
    13. Lin, C. H., Chen, C. H., Lin, Z. C., & Fang, J. Y. (2017). Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. Journal of Food and Drug Analysis, 25(2), 219–234. https://doi.org/10.1016/j.jfda.2017.02.001
    14. Mehnert, W., & Mäder, K. (2001). Solid lipid nanoparticles: Production, characterization and applications. Advanced Drug Delivery Reviews, 47(2–3), 165–196. https://doi.org/10.1016/S0169-409X(01)00105-3
    15. Mishra, V., Bansal, K. K., Verma, A., Yadav, N., Thakur, S., Sudhakar, K., & Rosenholm, J. M. (2018). Solid lipid nanoparticles: Emerging colloidal nano drug delivery systems. Pharmaceutics, 10(4), 1–21. https://doi.org/10.3390/pharmaceutics10040191
    16. Müller, R. H., Mäder, K., & Gohla, S. (2000). Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics, 50(1), 161–177. https://doi.org/10.1016/S0939-6411(00)00087-4
    17. Patel, V. F., Liu, F., & Brown, M. B. (2011). Advances in oral transmucosal drug delivery. Journal of Controlled Release, 153(2), 106–116. https://doi.org/10.1016/J.JCONREL.2011.01.027
    18. Salamat-Miller, N., Chittchang, M., & Johnston, T. P. (2005). The use of mucoadhesive polymers in buccal drug delivery. Advanced Drug Delivery Reviews, 57(11), 1666–1691. https://doi.org/10.1016/j.addr.2005.07.003
    19. Shaikh, R., Raj Singh, T., Garland, M., Woolfson, A., & Donnelly, R. (2011). Mucoadhesive drug delivery systems. Journal of Pharmacy and Bioallied Sciences, 3(1), 89–100. https://doi.org/10.4103/0975-7406.76478
    20. Tzanova, M. M., Hagesaether, E., & Tho, I. (2021). Solid lipid nanoparticle-loaded mucoadhesive buccal films – Critical quality attributes and in vitro safety & efficacy. International Journal of Pharmaceutics, 592, 120100. https://doi.org/10.1016/J.IJPHARM.2020.120100
    21. Wong, C. F., Yuen, K. H., & Peh, K. K. (1999). Formulation and evaluation of controlled release Eudragit buccal patches. International Journal of Pharmaceutics, 178(1), 11–22. https://doi.org/10.1016/S0378-5173(98)00342-1
    22. Woodley, J. (2001). Bioadhesion. Clinical Pharmacokinetics, 40(2), 77–84. https://doi.org/10.2165/00003088-200140020-00001
    23. Yedurkar, P., Dhiman, M. K., Petkar, K., & Sawant, K. (2012). Mucoadhesive bilayer buccal tablet of carvedilol-loaded chitosan microspheres: In vitro, pharmacokinetic and pharmacodynamic investigations. Journal of Microencapsulation, 29(2), 126–137. https://doi.org/10.3109/02652048.2011.630109
    24. Yehia, S. A., El-Gazayerly, O. N., & Basalious, E. B. (2008). Design and in vitro/in vivo evaluation of novel mucoadhesive buccal discs of an antifungal drug: Relationship between swelling, erosion, and drug release. AAPS PharmSciTech, 9(4), 1207–1217. https://doi.org/10.1208/s12249-008-9166-1
    25. Zewail, M. B., F.Asaad, G., Swellam, S. M., Abd-allah, S. M., K.Hosny, S., Sallah, S. K., E.Eissa, J., S.Mohamed, S., & El-Dakroury, W. A. (2022). Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in experimental inflammation. International Journal of Pharmaceutics, 624, 122006. https://doi.org/10.1016/J.IJPHARM.2022.122006

    How to Cite

    Neelakandan, R. P. ., R, D. ., & N, D. . (2023). Formulation and Evaluation of Mucoadhesive Buccal tablets using Nimodipine Solid Lipid Nanoparticles. Nanofabrication, 8. https://doi.org/10.37819/nanofab.008.296
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    Remya Prabhavathi Neelakandan
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    Divya R
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    Damodharan N
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    Article Details

    DOI: https://doi.org/10.37819/nanofab.008.296

    Published: 2023-02-11

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    Copyright (c) 2023 Remya Prabhavathi Neelakandan, Divya R, Damodharan N

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