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    Formulation and Evaluation of Mucoadhesive Buccal tablets using Nimodipine Solid Lipid Nanoparticles



    Abstract

    This study aimed to create and describe mucoadhesive nimodipine solid lipid nanoparticles as buccal tablets by altering the amounts of three polymers: Carbopol 934, Hydroxypropyl methylcellulose and Hydroxyethyl cellulose. The Nimodipine-loaded solid lipid nanoparticles (SLN) were formulated by high shear homogenization and ultrasonication process using palmitic and stearic acid as the lipid matrix and Tween-80 as the surfactant. The swelling properties of all formulations were investigated, and it was discovered that all formulations have a good swelling index at 6 hours. The surface pH of each batch varied between 5.6 and 6.1. The mucoadhesive strengths (15.3-29.5 g) varied with polymer concentrations, particularly Carbopol 934. All batches had considerably different dissolution profiles, ranging from a maximum release of 89.08% (at 8h in batch NT3) to a minimum release of 80.32% (at 8h in batch NT2). SLN formulations had the best results in both Entrapment efficiency and In-vitro drug release, showing that SLN may be a promising delivery strategy for improving Nimodipine release.

    Keywords: Nimodipine Mucoadhesive buccal tablets Carbopol 934 Hydroxypropyl methylcellulose Hydroxyethyl cellulose Solid lipid nanoparticles
    Section

    References

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    How to Cite

    Neelakandan, R. P. ., R, D. ., & N, D. . (2023). Formulation and Evaluation of Mucoadhesive Buccal tablets using Nimodipine Solid Lipid Nanoparticles. Nanofabrication, 8. https://doi.org/10.37819/nanofab.008.296
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    Remya Prabhavathi Neelakandan
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    Divya R
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    Damodharan N
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    Article Details

    DOI: https://doi.org/10.37819/nanofab.008.296

    Published: 2023-02-11

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    Copyright (c) 2023 Remya Prabhavathi Neelakandan, Divya R, Damodharan N

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