Skip to main content Skip to main navigation menu Skip to site footer

Standardized Operational Protocol for the China Human Brain Bank Consortium

  • Wang Xue
  • Wu Juanli
  • Wang Naili
  • Zhang Di
  • Chen Zhen
  • Zhang Hanlin
  • Zhu Keqing
  • Bao Aimin
  • Zhang Jing
  • Shen Yi
  • Qian Xiaojing
  • Qiu Wenying

Abstract

The study of post-mortem human brains is fundamental to the discovery and diagnosis of most neurological diseases and an in-depth understanding of brain structure, function and disorders. Human brain banks use a standardized protocol to collect, process, and store post-mortem human brains and related tissues, together with relevant clinical information, and to provide the tissue samples and data to foster neuroscience research. A Standardized Operational Protocol (SOP) that is approved by and can be abided by all of the human brain banks in the China Human Brain Bank Consortium is critical to developing brain research in China. The first SOP of human brain banking in China was published in 2017 following the foundation of the China Human Brain Bank Consortium. So far, 20 members from different regions in China have joined the consortium, forming a nationwide collaboration network of human brain banks. To provide brain tissue samples of good quality and consistency to meet the increasing demand for neuroscience research, a revised SOP was drafted by experts from the China Human Brain Bank Consortium. Significant improvements in this new version of SOP include strengthened ethical guidelines, recruitment of matching controls, and more brain regions to be sampled for neuropathological evaluation.

Section

References

  1. Bahn, S., Augood, S. J., Ryan, M., Standaert, D. G., Starkey, M., & Emson, P. C. (2001). Gene expression profiling in the post-mortem human brain--no cause for dismay. J Chem Neuroanat, 22(1-2), 79-94. doi:10.1016/s0891-0618(01)00099-0
  2. Bell, J. E., Alafuzoff, I., Al-Sarraj, S., Arzberger, T., Bogdanovic, N., Budka, H., . . . Kretzschmar, H. (2008). Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium. Acta Neuropathol, 115(5), 497-507. doi:10.1007/s00401-008-0360-8
  3. Bigio, E. H. (2013). Making the diagnosis of frontotemporal lobar degeneration. Arch Pathol Lab Med, 137(3), 314-325. doi:10.5858/arpa.2012-0075-RA
  4. Cairns, N. J., Bigio, E. H., Mackenzie, I. R., Neumann, M., Lee, V. M., Hatanpaa, K. J., . . . Consortium for Frontotemporal Lobar, D. (2007). Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol, 114(1), 5-22. doi:10.1007/s00401-007-0237-2
  5. Committee, P. (2014). Sandardized Opeation Protocol for Human Brain Banking in China (draft). Basic & Clincal Medicine, 34(11), 24-50.
  6. Del Tredici, K., & Braak, H. (2016). Review: Sporadic ” ’Parkinson’s disease: development and distribution of α-synuclein pathology. Neuropathol Appl Neurobiol, 42(1), 33-50. doi:10.1111/nan.12298
  7. Deramecourt, V., Slade, J. Y., Oakley, A. E., Perry, R. H., Ince, P. G., Maurage, C. A., & Kalaria, R. N. (2012). Staging and natural history of cerebrovascular pathology in dementia. Neurology, 78(14), 1043-1050. doi:10.1212/WNL.0b013e31824e8e7f
  8. Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., . . . Litvan, I. (2009). Neuropathological assessment of ” ’Parkinson’s disease: refining the diagnostic criteria. Lancet Neurol, 8(12), 1150-1157. doi:10.1016/S1474-4422(09)70238-8
  9. Dutra, J. R., Cortes, E. P., & Vonsattel, J. P. (2015). Update on Hippocampal Sclerosis. Curr Neurol Neurosci Rep, 15(10), 67. doi:10.1007/s11910-015-0592-7
  10. Farias, S. T., Weakley, A., Harvey, D., Chandler, J., Huss, O., & Mungas, D. (2021). The Measurement of Everyday Cognition (ECog): Revisions and Updates. Alzheimer Dis Assoc Disord, 35(3), 258-264. doi:10.1097/WAD.0000000000000450
  11. Jellinger, K. A., & Attems, J. (2007). Neuropathological evaluation of mixed dementia. J Neurol Sci, 257(1-2), 80-87. doi:10.1016/j.jns.2007.01.045
  12. Kretzschmar, H. (2009). Brain banking: opportunities, challenges and meaning for the future. Nat Rev Neurosci, 10(1), 70-78. doi:10.1038/nrn2535
  13. Mackenzie, I. R., Neumann, M., Bigio, E. H., Cairns, N. J., Alafuzoff, I., Kril, J., . . . Mann, D. M. (2010). Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol, 119(1), 1-4. doi:10.1007/s00401-009-0612-2
  14. McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J. P., Weintraub, D., . . . Kosaka, K. (2017). Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology, 89(1), 88-100. doi:10.1212/wnl.0000000000004058
  15. Mehta, P., Kaye, W., Raymond, J., Punjani, R., Larson, T., Cohen, J., . . . Horton, K. (2018). Prevalence of Amyotrophic Lateral Sclerosis - United States, 2015. MMWR Morb Mortal Wkly Rep, 67(46), 1285-1289. doi:10.15585/mmwr.mm6746a1
  16. Mighdoll, M. I., & Hyde, T. M. (2018). Brain donation at autopsy: clinical characterization and toxicologic analyses. Handb Clin Neurol, 150, 143-154. doi:10.1016/B978-0-444-63639-3.00011-6
  17. Nelson, P. T., Schmitt, F. A., Lin, Y., Abner, E. L., Jicha, G. A., Patel, E., . . . Kryscio, R. J. (2011). Hippocampal sclerosis in advanced age: clinical and pathological features. Brain, 134(Pt 5), 1506-1518. doi:10.1093/brain/awr053
  18. Neumann, M., Rademakers, R., Roeber, S., Baker, M., Kretzschmar, H. A., & Mackenzie, I. R. (2009). A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain, 132(Pt 11), 2922-2931. doi:10.1093/brain/awp214
  19. Preece, P., & Cairns, N. J. (2003). Quantifying mRNA in post-mortem human brain: influence of gender, age at death, post-mortem interval, brain pH, agonal state and inter-lobe mRNA variance. Brain Res Mol Brain Res, 118(1-2), 60-71. doi:10.1016/s0169-328x(03)00337-1
  20. Pringsheim, T., Fiest, K., & Jette, N. (2014). The international incidence and prevalence of neurologic conditions: how common are they? Neurology, 83(18), 1661-1664. doi:10.1212/wnl.0000000000000929
  21. Qiu W, M. C., Bao A, Zhu K, Huang Y, Yan x, et al. . (2017). Standardized operational protocol for human brain banking in China. Acta Anatomica Sinica, 48(3), 334-341.
  22. Qiu, W., Zhang, H., Bao, A., Zhu, K., Huang, Y., Yan, X., . . . Ma, C. (2019). Standardized Operational Protocol for Human Brain Banking in China. Neurosci Bull, 35(2), 270-276. doi:10.1007/s12264-018-0306-7
  23. Qiu, W. Y., Yang, Q., Zhang, W., Wang, N., Zhang, D., Huang, Y., & Ma, C. (2018). The Correlations between Postmortem Brain Pathologies and Cognitive Dysfunction in Aging and ” ’Alzheimer’s Disease. Curr Alzheimer Res, 15(5), 462-473. doi:10.2174/1567205014666171106150915
  24. Ross, B. M., Knowler, J. T., & McCulloch, J. (1992). On the stability of messenger RNA and ribosomal RNA in the brains of control human subjects and patients with ” ’Alzheimer’s disease. J Neurochem, 58(5), 1810-1819. doi:10.1111/j.1471-4159.1992.tb10057.x
  25. Sachdev, P. S., Blacker, D., Blazer, D. G., Ganguli, M., Jeste, D. V., Paulsen, J. S., & Petersen, R. C. (2014). Classifying neurocognitive disorders: the DSM-5 approach. Nat Rev Neurol, 10(11), 634-642. doi:10.1038/nrneurol.2014.181
  26. Schellenberg, G. D., & Montine, T. J. (2012). The genetics and neuropathology of ” ’Alzheimer’s disease. Acta Neuropathol, 124(3), 305-323. doi:10.1007/s00401-012-0996-2
  27. Tang, K., Wan, M., Zhang, H., Zhang, Q., Yang, Q., Chen, K., . . . Ma, C. (2020). The top 100 most-cited articles citing human brain banking from 1970 to 2020: a bibliometric analysis. Cell Tissue Bank, 21(4), 685-697. doi:10.1007/s10561-020-09849-w
  28. Tay, L., Lim, W. S., Chan, M., Ali, N., Mahanum, S., Chew, P., . . . Chong, M. S. (2015). New DSM-V neurocognitive disorders criteria and their impact on diagnostic classifications of mild cognitive impairment and dementia in a memory clinic setting. Am J Geriatr Psychiatry, 23(8), 768-779. doi:10.1016/j.jagp.2015.01.004
  29. Tomaszewski Farias, S., Mungas, D., Harvey, D. J., Simmons, A., Reed, B. R., & Decarli, C. (2011). The measurement of everyday cognition: development and validation of a short form of the Everyday Cognition scales. Alzheimers Dement, 7(6), 593-601. doi:10.1016/j.jalz.2011.02.007
  30. Trojanowski, J. Q., Revesz, T., & Neuropathology Working Group on, M. S. A. (2007). Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy. Neuropathol Appl Neurobiol, 33(6), 615-620. doi:10.1111/j.1365-2990.2007.00907.x
  31. Tsai, C. P., Wang, K. C., Hwang, C. S., Lee, I. T., & Lee, C. T. (2015). Incidence, prevalence, and medical expenditures of classical amyotrophic lateral sclerosis in Taiwan, 1999-2008. J Formos Med Assoc, 114(7), 612-619. doi:10.1016/j.jfma.2013.01.008
  32. Vonsattel, J. P., Amaya Mdel, P., Cortes, E. P., Mancevska, K., & Keller, C. E. (2008). Twenty-first century brain banking: practical prerequisites and lessons from the past: the experience of New York Brain Bank, Taub Institute, Columbia University. Cell Tissue Bank, 9(3), 247-258. doi:10.1007/s10561-008-9079-y
  33. Vonsattel, J. P., Myers, R. H., Stevens, T. J., Ferrante, R. J., Bird, E. D., & Richardson, E. P., Jr. (1985). Neuropathological classification of ” ’Huntington’s disease. J Neuropathol Exp Neurol, 44(6), 559-577.
  34. Yan, X. X., Ma, C., Bao, A. M., Wang, X. M., & Gai, W. P. (2015). Brain banking as a cornerstone of neuroscience in China. Lancet Neurol, 14(2), 136. doi:10.1016/S1474-4422(14)70259-5
  35. Yang, Q., Chen, K., Zhang, H., Zhang, W., Gong, C., Zhang, Q., . . . Ma, C. (2019). Correlations Between Single Nucleotide Polymorphisms, Cognitive Dysfunction, and Postmortem Brain Pathology in ” ’Alzheimer’s Disease Among Han Chinese. Neurosci Bull, 35(2), 193-204. doi:10.1007/s12264-019-00343-2
  36. Zhang, H., Chen, K., Wang, N., Zhang, D., Yang, Q., Zhang, Q., . . . Ma, C. (2018). Analysis of Brain ’”Donors’ Demographic and Medical Characteristics to Facilitate the Construction of a Human Brain Bank in China. J Alzheimers Dis, 66(3), 1245-1254. doi:10.3233/jad-180779

How to Cite

Xue, Wang, et al. “Standardized Operational Protocol for the China Human Brain Bank Consortium”. Human Brain, vol. 1, no. 1, Oct. 2022, pp. 92–106, doi:10.37819/hb.001.001.0209.

HTML
203

Total
116 7

Share

Downloads

Article Details

Most Read This Month

License

Copyright (c) 2022 WANG Xue, SHEN Yi, WU Juanli, ZHU Keqing, WANG Naili, CHEN Zhen, BAO Aimin, ZHANG Jing, QIAN Xiaojing, QIU Wenying

Creative Commons License

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.