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    Microglia Heterogeneity: A Single-cell Concerto

    • Leilei Wang
    • Haoran Wu
    • Shanshan Zhang
    • Dingxian He
    • Yi Chen
    • Jingxin Xue
    • Linya You
    • Qiong Liu
    • Wensheng Li


    Abstract

    Microglia are tissue-resident macrophages of the central nervous system (CNS) that play crucial roles in development, homeostasis, and response to perturbation. Microglia react to the surrounding environment in a context-dependent manner. However, research on microglial heterogeneity is limited, given the lack of high-resolution and high-sensitivity methods. Recent studies have demonstrated the heterogeneity of microglia on a spatial-temporal scale, benefiting from the advancement of single-cell technologies. Here, we review the current knowledge about microglial diversity during physiological and pathological conditions in humans and mice.

    Keywords: microglia heterogeneity single-cell technologies disease-associated microglia
    Section

    References

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    How to Cite

    Wang, Leilei, et al. “Microglia Heterogeneity: A Single-Cell Concerto”. Human Brain, vol. 1, no. 1, July 2022, pp. 77–91, doi:10.37819/hb.001.001.0208.
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    DOI: https://doi.org/10.37819/hb.001.001.0208

    Published: 2022-07-12

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