Aqueous extract of B.Pinnatum causes significant reduction in urinary calcium excretion inethylene glycol induced renal calculi rat model.
Abstract
INTRODUCTION: Nephrolithiasis is one of the commonest worldwide problem. Treatment options for nephrolithiasis are shock wave lithotripsy, percutaneous nephrolithotomy and laproscopic removal which are costly procedures and are associated with adverse effects which have motivated human to return for safer remedies by nature as herbal medication. Bryophyllum pinnatum has been used in traditional medicine for treatment of renal stones but scientific data is lacking.
OBJECTIVE: To evaluate the effect of aqueous extract of Bryophyllum pinnatum leaf on treatment of calcium oxalate nephrolithiasis in a rat model.
METHODOLOGY: 32 rats were divided into 4 groups as negative and positive control, low and high dose treatment groups. Nephrolithiasis was induced by 1% ethylene glycol and vitamin D3 which were given throughout the study period of 28 days. Treatment groups received aqueous leaf extract of Bryophyllum pinnatum from day 14 to 28. Urine calcium was estimated on day 0, 14 and 28.
RESULTS: The aqueous extractofBryophyllum pinnatumsignificantly (p<0.05) lowered the elevated urine calcium..
CONCLUSION: From this study it can be concluded that aqueous extract of Bryophyllum pinnatum leavespossess litholytic activity in ethylene glycol induced nephrolithiasis.
KEY WORDS: Effectiveness, Kidney stone, Bryophyllum pinnatum, Litholytic, Calcium oxalate.
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