Evaluation of serum levels of C - reactive protein and Magnesium in Type II Diabetes patients
Abstract
INTRODUCTION: Increase blood sugar level in blood is due to the metabolic disorder called as Diabetes Mellitus, which occur either due to decrease insulin production or because of the cells that do not respond to the insulin in blood. Majorly type 1 diabetes is of the immune-mediated in nature, in which beta cell loss is a T-cell-mediated autoimmune attack. Type 2 diabetes mellitus occur due to insulin resistance, which may be combined with relatively reduced insulin secretion. The defective responsiveness of body tissues to insulin is believed to involve the insulin receptor
OBJECTIVE: To find out the serum c reactive proteins and magnesium levels in type II diabetes mellitus patients.
METHODOLOGY: This was cross sectional comparative study. A total of one hundred and forty (140). Of these 70 patients ranging age 30-50 years) were diabetic and the remaining 70 patients (same age as diabetes) were non-diabetic. The duration of the study was six month. One hundred forty (140) serum samples from age and gender matched diabetic and non-diabetic were investigated for the levels of C- reactive proteins by Nyocard kit methods and magnesium by standard kit methods using Diasys kit.
RESULTS: Diabetic in comparison to non-diabetic had significantly raised mean serum C-reactive proteins (40.23±3.05 Vs 4.70±1.14; P<0.001) and magnesium (1.61 ± 0.56 Vs 2.56 ± 0.18, P<0.001) levels.
CONCLUSION: The result clearly shows that C-Reactive protein is a good marker for the detection of diabetes in young patients of age 30 – 50 years.
KEY WORDS: Diabetes Mellitus, C- Reactive proteins.
References
Shoback, edited by David G. Gardner, Dolores (2011). Greenspan’s basic & clinical endocrinology (9th ed.). New York: McGraw-Hill Medical. pp. Chapter 17.
Rother KI (April 2007). “Diabetes treatment—bridging the divideâ€. The New England Journal of Medicine 356 (15): 1499–501.
Dorner M, Pinget M, Brogard JM (May 1977). “Essential labile diabetesâ€. MMW Munch Med Wochenschr (in German) 119 (19): 671–4.
Emerging Risk Factors Collaboration (2010). “Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studiesâ€. The Lancet 375 (9733): 2215–22.
Cukierman, T (8 Nov 2005). “Cognitive decline and dementia in diabetes—systematic overview of prospective observational studiesâ€. Springer-Verlag. Retrieved 28 Apr 2013.
Linsley, Trevor. “Properties of conductors and insulatorsâ€. Basic Electrical Installation Work. p. 362.
Euser, A. G.; Cipolla, M. J. (2009). “Magnesium Sulfate for the Treatment of Eclampsia: A Brief Reviewâ€. Stroke 40 (4): 1169–1175.
“Magnesiumâ€. University of Maryland Medical Center 2011.
Arnaud MJ (2008). “Update on the assessment of magnesium statusâ€. Br. J. Nutr. 99 Suppl 3: S24–36.
Larsson SC, Virtanen MJ, Mars M, et al. “Magnesium, calcium, potassium, and sodium intakes and risk of stroke in male smokersâ€. Arch. Intern. Med. 168 (5): 459–65.
KETIL A; TERJE KR; AUNE PER( 2002), “Magnesium†in Ullmann’s Encyclopedia of Industrial Chemistry.
Barragan–Rodriguez L, Rodriguez–Moran M, Guerrero-Romero F. “Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type2 diabetes: a randomized, equivalent trial.†Magnes Res, 2008, 21(4); 218-23.
LAU, DC; DHILLON, B; YAN, H; SZMITKO, PE; VERMA, S ( 2005), “Adipokines: molecular links between obesity and atheroslcerosisâ€. Am J Physiol Heart Circ Physiol 288 (5): H2031–41.
Pepys, MB; Hirschfield, GM ( 2003), “C-reactive protein: a critical update†(PDF). J Clin Invest 111 (12): 1805–1812.
DEHGHAN A; KARDYS, I; DE MAAT, MP; UITTERLINDEN, AG; SIJBRANDS, EJ; BOOTSMA, AH; STIJNEN, T; HOFMAN, A et al. ( 2007) “Genetic variation, C-reactive protein levels, and incidence of diabetesâ€. Diabetes 56 (3): 872–8.
LOPEZ-GARCIA E; SCHULZE MB; MEIGS JB; MANSON JE; RIFAI N; STAMPFER MJ; WILLETT WC; HU FB (2005), “Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction.
Baskurt, Oguz K., and Herbert J. Meiselman. “Blood rheology and hemodynamics.†Seminars in thrombosis and hemostasis. Vol. 29. No. 5. New York: Stratton Intercontinental Medical Book Corporation, c1974-, 2003.
Tefferi A (May 2003). “A contemporary approach to the diagnosis and management of polycythemia veraâ€. Curr. Hematol. Rep. 2 (3): 237–41.
Lenz C, Rebel A, Waschke KF, Koehler RC, Frietsch T (2008). “Blood viscosity modulates tissue perfusion: sometimes and somewhereâ€. Transfus Altern Transfus Med 9 (4): 265–272.
Kwon O, Krishnamoorthy M, Cho YI, Sankovic JM, Banerjee RK (February 2008). “Effect of blood viscosity on oxygen transport in residual stenosed artery following angioplastyâ€. J Biomech Eng 130 (1): 011003.
Noble C N, Penny BB, comparison of leukocyte count & function in smoking & non-smoking men infect Immun. 1975; 12:550-5.
DAS Raised C-reactive protein levels in serum from smokers. Clin Chim Acta. 1985;153:9–13.
MALPUECH-BRUGÉRE C, NOWACKI W, DAVEAU M, GUEUX E, LINARD C, ROCK E, LEBRETON J, MAZUR A, RAYSSIGUIER Y. Inflammatory response following acute magnesium deficiency in the rat. Biochim Biophys Acta (2000), 1501: 91-98.
Dana E; KING MD; ARCH G. et al., (2005) “Dietary Magnesium and C-reactive protein levelsâ€. J. Am col of Nutrition 24(3): 166-171
GUERRERO-ROMERO F, RODRIGUEZ-MORAN M. relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects. Int J. Obes Relat Metab Disord 26: 469-474, 2002).
Maria de Lourdes lima, Thomas cruz, Judith carreiro pousda, Rua coronel Arthur Gomes de carvallo, 537/402 – pituba, Salvador – Bahia – Brazil Cep: 41.820 – 110.
Yiqing song,Julie E buring, Joann E,Manson and Simin liu,â€Dietary magenssium intakein relation to plasma insulin levels and risk of type 2 diabetes in womenâ€. Diabetes care volume 27, number 1, January 2004.
