Use of CD138 as Diagnostic Tool for Chronic Endometritis in Infertility

Abstract

Background: Chronic endometritis (CE) can present in different ways. Various studies have proved the association between CE and infertility. As the data on the analysis of CD138 immunostain as a diagnostic tool for CE is scarce, this study was designed to compare CD138 with H&E for the diagnosis of CE.

Objective: To compare the results of CD138 immunostain with Hematoxylin and Eosin staining for diagnosis of chronic endometritis.

Methodology: Study design: Cross-sectional study. Place of study: Shifa International Hospital, Islamabad. Duration of study: January to September 2018. A total of 100 patients meeting selection criteria were included in the study. All patients had at least one-year history of infertility. Specimen were assessed on both H&E and CD138 immunostain and then results were compared. Data were analyzed by using SPSS version 20.

Results: A total of 100 biopsies from females having infertility were included in the study. The mean age of patients was 33.4±4.3 years. A total of 32 out of 100 cases were found to be positive on H&E stain and 36 cases were positive on CD138 and  27 cases were true positive and 59 were true negative.

Conclusion: CD138 has increased sensitivity in diagnosing Chronic Endometritis as comparing it with conventional H&E staining.